Monday, September 6, 2010

Thought Experiment on PRDM

Thought Experiment #1

PRDM9 micro-satellites involved with human diversity by modulating the hotspots on the DNA. The PRDM (Positive Regulatory Domain Modulator) gene encodes for a protein which is a Zinc Finger transcriptor and this resides within the nucleus to modulate transcription into the DNA of the cell and modulate the proliferation of the cell with the variance to encode diversity – genetic for propagation and cellular to withstand stressors.

PRDM 16 on Chromosome 1

Interesting that PRDM16 is involved in a similar pathway but one of the known issues with PRDM16 is that in a t(1:3) (p36-q21) a subsets of MDS (Myelodysplastic Syndrome) and AML (Acute Myeloid Leukemia) cases have been identified.
Further viral infections lead to over-expression of the PRDM16 gene.
Question: DO sometimes clustering of Acute Leukemia cases represent a viral infection and the subsequent translocations through the PRDM genetic gateway?

Reference: Nature Genetics September 2010.

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